From Natural Products to Drug Discovery

• Awale S., Ueda J., Athikomkulchai S., Dibwe D. F., Abdelhamed S., Yokoyama S., Saiki I., Miyatake R.
  Uvaridacols E-H, Highly Oxygenated Antiausterity Agents from Uvaria dac
  J. Nat. Prod. 2012, 75, 1999-2002.

• Dibwe D.F., Awale S., Kadota S. Tezuka Y.
  Muchimangins A–D: novel  diphenylmethyl-substituted xanthones from Securidaca longepedunculata
  Tetrahedron Lett. 2012, 53, 6186-6190.

• Awale S., Ueda J., Athikomkulchai S., Abdelhamed S., Yokoyama S., Saiki I., Miyatake R.
  Antiausterity Agents from Uvaria dac and Their Preferential Cytotoxic Activity against Human Pancreatic Cancer Cell Lines in a Nutrient-Deprived Condition
  J. Nat. Prod. 2012, 75, 1177-1183.

• Dibwe D. F., Awale S., Kadota S., Tezuka Y.
  Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cells
  Phytother Res. 2012, 26, 1920-1926.

• Awale S., Linn TZ., Feng L., Tezuka Y., Myint A., Tomida A., Yamori T., Esumi H., Kadota S.
  Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC-1 and a Panel of 39 Human Cancer Cell Lines (JFCR-39)
  Phytother. Res. 2011, 25, 1770-1775.

• Devji T., Reddy C., Woo C., Awale S., Kadota S., Carrico-Moniz D.
  Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative
  Bioorg. Med. Chem. Lett., 2011, 21, 5770-5773.

• Li F., He Y., Awale S., Kadota S., Tezuka Y.
  Two new cytotoxic phenylallylflavanones from mexican propolis
  Chem. Pharm. Bull. 2011, 59, 1194-1196.

• Tezuka Y., Morikawa K., Li F., Auw L., Awale S., Nobukawa T., Kadota S.
  Cytochrome P450 3A4 Inhibitory Constituents of the Bark of Taxus yunnanensis
  J. Nat. Prod. 2011, 74, 102-105.

• Thapaliya E. R., Kalauni S. K., Awale S., Adhikari A., Chaudhary M. I., and Mahandhar M. D.
  Isolation and characterization of neoflavonoid and a fatty acids from propolis of Apis mellifera of Nepal
  J. Alp. Chem. 2011, 2, 24-29.

• Kharel P., Manandhar M.D., Kalauni S. K., Awale S., Baral J.
  Isolation, identification and antimicrobial activity of withanolide WS-1 from roots of Withania somnifera
  Nep. J. Sci. Tech. 2011, 12, 179-186.

• Dhakal R. C., Kalauni S. K., Awale S., Shrestha K., Gewali M. B.
  Isolation and characterization of sterols and an aliphatic alcohol from Tsuga dumosa D. Don of Nepal
  Scientific World, 2011, 9, 16-17.

• Widyowati R., Tezuka Y., Miyahara T., Awale S., Kadota S.
  Alkaline Phosphatase (ALP) Enhancing Iridoid Glucosides from the Indonesian Medicinal Plant Barleria lupulina
  Nat. Prod. Commun. 2010, 5, 1711-1716.

• Feng L., Awale S., Tezuka Y., Kadota S.
  Cytotoxicity of Constituents from Mexican Propolis Against a Panel of Six Different Cancer Cell Lines
  Nat. Prod. Commun. 2010, 5, 1601-1606.

• Morikawa K., Tanaka K., Li F., Awale S., Tezuka Y., Nobukawa T., Kadota S.
  Analysis of MS/MS fragmentation of taxoids
  Nat. Prod. Commun. 2010, 5, 1551-1556.

• Miyake K., Feng L., Tezuka Y., Awale S., and Kadota S.
  Cytotoxic Activity of Quasinnoids from Eurycoma longifolia
  Nat. Prod. Commun. 2010, 5, 1009-1012.

• Feng L., Awale S., Tezuka Y., Esumi H., Kadota S.
  Study on the Constituents of Mexican Propolis and their Cytotoxic Activity Against PANC-1 Human Pancreatic Cancer Cells
  J. Nat. Prod. 2010, 73, 623-627.

• Miyake K., Tezuka Y., Awale S., Feng L., and Kadota S.
  Canthin-6-one Alkaloids and a Tirucallanoid from Eurycoma longifolia Jack and Their Cytotoxic Activity against Human HT-1080 Fibrosarcoma Cell Line
  Nat. Prod. Commun. 2010, 5, 17-22.

• Miyake K., Tezuka Y., Awale S., Feng L., Kadota S.
  Quassinoids from Eurycoma longifolia Jack
  J. Nat. Prod. 2009, 72, 2135-2140.

• Feng L., Awale S., Tezuka Y.,, Kadota S.
  Cytotoxic activity of the constituents of propolis from Myanmar against a panel of six cancer cell line and their structure-activity relationship
  Biol. Pharm. Bull. 2009, 32, 2075-2078.

• Dhakal R., Rajbhandari M., Kalauni S.K., Awale S., Gewali M.B.
  Phytochemical constituents of the bark of Vitex negundo L.
  J. Nep. Chem. Soc. 2009, 23, 89-92.

• Awale S., Miyamoto T., Linn T.Z., Feng L., Win N.N.,Tezuka Y., Esumi H., Kadota S.
  Cytotoxic constituents Soymida febrifuga from Myanmar
  J. Nat. Prod. 2009, 72, 1631-1636.

• Feng L., Awale S., Zhang H., Tezuka Y., Esumi H., Kadota S.
  Chemical Constituents of Propolis from Myanmar and Their Preferential Cytotoxicity against a PANC-1 Human Pancreatic Cancer Cell Line
  J. Nat. Prod. 2009, 72, 1283-1287.

• Awale S., Hamazaki T., Kadowaki M., Saiki I., Tezuka Y., Kadota S.
  Commonly Encountered Diseases in Traditional Medicine in Myanmar Traditional Medicine Handbook Published by Department of Traditional Medicine, Ministry of Health and Japan International Cooperation Agency (JICA), 89-120, 2008

• Win N.N., Awale S., Esumi H., Tezuka Y., Kadota S.
  Novel Anticancer Agents, Kayeassamins C-I from the Flower of Kayea assamica of Myanmar
  Bioorg. Med. Chem. 2008, 16, 8653-8660.

• Win N.N., Awale S., Esumi H., Tezuka Y., Kadota S.
  Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar
  Bioorg. Med. Chem. Lett. 2008, 18, 4688-4691

• Feng L., Awale S., Tezuka Y., Kadota S.
  Cytotoxic constituents from Brazilian red propolis and their structure–activity relationship
  Bioorg. Med. Chem. 2008, 16, 5434-5440

• Win N. N., Awale S., Esumi H., Tezuka Y., Kadota S.
  Panduratins D—I, Novel Secondary Metabolites from Rhizomes of Boesenbergia pandurata
  Chem. Pharm. Bull. 2008, 56, 491-496.

• Awale S., Feng L., Onozuka H., Esumi H., Tezuka Y., Kadota S.
  Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line under nutrient deprived condition
  Bioorg. Med. Chem. 2008, 16, 181-189.

• Win N. N., Awale S., Esumi H., Tezuka Y., Kadota S.
  Bioactive Secondary Metabolites from Boesenbergia pandurata of Myanmar and Their Preferential Cytotoxicity Against Human Pancreatic Cancer PANC-1 Cell Line Under Nutrient Deprived Condition
  J. Nat. Prod. 2007, 70, 1582-1587.

• Mangestuti, Subehan, Widyawaruyanti A., Zaidi S. F. H., Awale S., Kadota S.
  Traditional medicine of Madura island in Indonesia
  J. Trad. Med. 2007, 24, 90-103.

• Widyawaruyanti A., Subehan, Kalauni S. K., Awale S., Nindatu M., Zaini N. C., Syafruddin D., Asih P. B. S., Tezuka Y., Kadota S.
  New Prenylated Flavones from Atrocarpus champeden and their Antimalarial activity in vitro
  J Nat. Med. 2007, 61, 410-413.

• Awale S., Linn T.Z., Than M.M., Thet M. M., Swe T., Saiki I., Kadota S.
  An amazing cow’s urine therapy practice in Myanmar
  J. Trad. Med. 2006, 23, 178-183.

• Awale S., Lu J., Kalauni S. K., Kurashima Y., Tezuka Y., Kadota S., Esumi H.
  Identification of arctigenin as an Anti-tumor Agent having activity to Eliminate Cancer Cell’s Tolerance to Nutrient Starvation
  Cancer Res. 2006, 66, 1751-1753.

• Awale S., Nakashima E. M. N., Kalauni S. K., Tezuka Y., Lu J., Kurashima Y., Esumi H., Kadota S.
  Angelmarin, a Novel Anticancer Agent Able to Eliminate the Tolerance of Cancer Cells to Nutrition Starvation
  Bioorg. Med. Chem. Lett. 2006, 16, 581-583.

• Ueda J., Awale S., Tezuka Y., Shimamura E., Hirai K., Nobukawa T., Kadota S.
  Growth Inhibitory Activity of Wood of Taxus yunnanensis and its Liquid Chromatography Fourier-Transform Mass Spectrometry Analysis
  Planta Med. 2006, 72, 1241-1244.

• Zaidi S. F. H., Awale S., Kalauni S. K., Tezuka Y., Esumi H., Kadota S.
  Diterpenes from Pini Resina and Their Preferential Cytotoxic Activity under Nutrient-Deprived Condition
  Planta Med. 2006, 72, 1231-1234.

• Awale S., Linn T.Z., Than M.M., Saiki I., Kadota S.
  The Healing Art of Traditional Medicines in Myanmar
  J. Trad. Med. 2006, 23, 47-68.

• Nguyen M. T., Tran Q.L., Nakashima E. M. N., Awale S., Kadota S.
  Investigation on traditional medicine at Phu uoc Island and Ninh Thuan Province in Vietnam
  J. Trad. Med. 2006, 23, 69-82.

• Awale S., Linn T.Z., Tezuka Y., Banskota A.H., Kalauni S.K., Attamimi F., Ueda J., Kadota S.
  Constituents of Caesalpinia crista from Indonesia
  Chem. Pharm. Bull. 2006, 54, 213-218.

• Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Asih P.B.S., Syafruddin D., Kadota S.
  Antimalarial Activity of Cassane- and Norcassane-type Diterpenes from Caesalpinia Crista and Their Structure-Activity Relationship
  Biol. Pharm. Bull. 2006, 29, 1050-1052.

• Nguyen M. T., Awale S., Tezuka Y., Ueda J., Tran Q.L., Kadota S.
  Xanthine Oxidase Inhibitors from the Flowers of Chrysanthemum sinense
  Planta med. 2006, 72, 46-51.

• Toyooka N., Kawasaki M., Nemoto H., Awale S., Tezuka Y., Kadota S.
  Synthetic studies on the poison-frog alkaloid 261C
  Synlett. 2005, 20, 3109-3110.

• Awale S., Kawakami T., Tezuka Y., Ueda J., Tanaka K., Kadota S.
  Nitric Oxide (NO) Production Inhibitory Constituents of Tabebuia avellanedae from Brazil
  Chem. Pharm. Bull. 2005, 53, 710-713.

• Awale S., Shrestha S. P., Tezuka Y., Ueda J., Matsushige K., Kadota S.
  Flavanoids from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity
  J. Nat. Prod. 2005, 68, 858-864.

• Nguyen M. T., Awale S., Tezuka Y., Shi L., Zaidi S. F. H., Ueda J., Tran Q.L., Murakami Y., Matsumoto K., Kadota S.
  Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats
  Biol. Pharm. Bull. 2005, 28, 2231-2234.

• Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
  Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar
  Chem. Pharm. Bull. 2005, 53, 1300-1304.

• Nguyen M. T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
  Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan
  Chem. Pharm. Bull. 2005, 53, 984-988. [See Hot off the press: Nat. Prod. Rep., 2005, 22, 559-562]

• Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
  New Cassane-type Diterpenes of Caesalpinia crista from Myanmar
  Chem. Pharm. Bull. 2005, 53, 214-218.

• Linn T.Z., Awale S., Tezuka Y., Banskota A.H., Kalauni S.K., Attamimi F., Ueda J., Asih P.B.S., Syafruddin D., Tanaka K., Kadota S.
  New Cassane- and Norcassane-type Diterpenes from Caesalpinia crista of Indonesia and Their Antimalarial Activity against the Growth of Plasmodium falciparum
  J. Nat. Prod. 2005, 68, 706-710.

• Gautam L. N., Awale S., Kalauni S. K., Shrestha S. and Gewali, M. B.
  Phytochemical and Biological Studies on Podocarpus nerifolius D. Don, A Himalayan Conifer of Nepal
  Scientific World, 2005.

• Awale S., Tezuka Y., Kobayashi M., Ueda J., Kadota S.
  Neoorthosiphonone A, a Nitric oxide (NO) Inhibitory Diterpene with a New Carbon Skeleton from Orthosiphon stamineus
  Tetrahedron Lett. 2004, 45, 1359-1362. [See Hot off the press: Nat. Prod. Rep., 2004, 21, H5-H8.]

• Kalauni S.K., Awale S., Tezuka Y., Banskota A.H., Linn T.Z., Kadota S.
  Cassane- and Norcassane-type Diterpenes from Caesalpinia crista from Myanmar
  J. Nat. Prod. 2004, 67, 1859-1863

• Nguyen M. T., Awale S., Tezuka Y., Tran Q.L., Kadota S.
  Neosappanone A, a Xanthine Oxidase (XO) Inhibitory Dimeric Methanodibenzoxocinone with a New Carbon Skeleton from Caesalpinia sappan
  Tetrahedron Lett. 2004, 45, 8519-8522 [See Hot off the press: Nat. Prod. Rep., 2004, 21, H23-H26.]

• Nguyen M. T., Awale S., Tezuka Y., Tran Q.L., Watanabe H., Kadota S.
  Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants
  Biol. Pharm. Bull. 2004, 27, 1414-1421.

• Nguyen M. T., Awale S., Tezuka Y., Chien-Hsiung C., Kadota S.
  Staminane- and Isopimarane-type Diterpenes from Orthosiphon stamineus of Taiwan and Their Nitric Oxide Inhibitory Activity
  J. Nat. Prod. 2004, 67, 654-658.
  
  

• Awale S., Tezuka Y., Banskota A. H., Kadota S.
  Siphonols A-E, Novel Potent Nitric Oxide Inhibitors From Orthosiphon Stamineus of Indonesia
  Bioorg. Med. Chem. Lett. 2003, 13, 31-35.

• Awale S., Tezuka Y., Banskota A. H., Adnyana I. K., Kadota S.
  Nitric Oxide Inhibitory Isopimarane-type Diterpenes from Orthosiphon stamineus of Indonesia
  J. Nat. Prod. 2003, 55, 2755-2758.

• Awale S., Tezuka Y., Banskota A. H., Kadota S.
  Inhibition of Nitric Oxide Production by Highly-Oxygenated Diterpenes of Orthosiphon stamineus and their Structure-Activity Relationship
  Bio. Pharm. Bull. 2003, 26, 468-473.

• Awale S., Tezuka Y., Banskota A. H., Adnyana I. K., Kadota S.
  Highly-Oxygenated Isopimarane-type Diterpenes from Orthosiphon stamineus of Indonesia and their Nitric Oxide Inhibitory Activity
  Chem. Pharm. Bull. 2003, 51, 268-275.

• Awale S., Wang S., Tezuka Y., Banskota A. H., Tran K. Q., Kadota S.
  Antioxidative and Antihepatotoxic Principles of Toucha
  J. Trad. Med. 2003, 20, 45-50.

• Banskota A. H., Tezuka Y., Nguyen N. T., Awale S., Nobukawa T., Kadota S.
  DPPH Radical Scavenging and Nitric Oxide Inhibitory Activities of the Constituents from the Wood of Taxus yunnanensis
  Planta Med. 2003, 69, 500-505.

• Awale S., Tezuka Y., Wang S., Kadota S.
  Facile and Regioselective Synthesis of Phenylpropanoid-substituted Flavan-3-ols
  Org. Lett. 2002, 4, 1707-1709.

• Awale S., Tezuka Y., Banskota A. H., Shimoji S., Taira K., Kadota S.
  Norstaminane- and Isopimarane-type Diterpenes of Orthosiphon stamineus From Okinawa
  Tetrahedron, 2002, 58, 5503-5512.

• Awale S., Tezuka Y., Shimoji S., Taira K., Kadota S.
  Secoorthosiphols A-C; Three Highly Oxygenated Secoisopimarane-type Diterpenes From Orthosiphon Stamineus
  Tetrahedron Lett. 2002, 43, 1473-1475.

• Awale S., Tezuka Y., Banskota A. H., Kouda K., Tun K. M., Kadota S.
  Four Highly Oxygenated Isopimarane-type Diterpenes of Orthosiphon stamineus
  Planta Med. 2002, 68, 286-288.

• Banskota A. H., Nagaoka T., Sumioka L. Y., Tezuka Y., Awale S., Midorikawa K., Matsushige K., Kadota S.
  Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines
  J. Ethnopharmacol. 2002, 80, 67-73.

• Awale S., Tezuka Y., Banskota A. H., Kouda K., Tun K. M., Kadota S.
  Five Novel Highly Oxygenated Diterpenes of Orthosiphon stamineus from Myanmar
  J. Nat. Prod. 2001, 64, 592-596.

• Ali M. S., Tezuka Y., Awale S., Banskota A. H., Kadota S.
  Six New Diarylheptanoids from the Seeds of Alpinia blepharocalyx
  J. Nat. Prod. 2001, 64, 289-293.

• Adnyana I K., Tezuka Y., Awale S., Banskota A. H., Tran K. Q., Kadota S.
  1-O-Galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-b-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare
  Planta Med. 2001, 67, 370-371.

• Tezuka Y., Stampoulis P., Banskota A. H., Awale S., Tran K. Q., Saiki I., Kadota S.
  Constituents of Vietnamese medicinal plant Orthosiphon stamineus
  Chem. Pharm. Bull. 2000, 48, 1711-1719.

• Adnyana I K., Tezuka Y., Awale S., Banskota A. H., Tran K. Q., Kadota S.
  Quadranosides VI-XI, six new triterpene glucosides from the seeds of Combretum quadrangulare
  Chem. Pharm. Bull. 2000, 48, 1114-1120.

• Gewali M. B., Amatya R., Rai R., Awale S., Schaumberg, G. D.
  Chemical analysis of industrial wastewater from Kathmandu Valley Ed: Chitrakar, R., Nepal Chemical Society, Katmandu, Nepal.
  Proc. Int. Semin. Water Environ. 1994,151-155.