From Natural Products to Drug Discovery

• Dibwe D. F., Awale S., Kadota S., Morita H., Tezuka Y.
  Muchimangins E and F: novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata
  Tetrahedron Lett., 2014, 55, 1916-1919
  
  
• Nguyen M.T.T., Nguyen N.T., Nguyen K.D.H., Dau H.T.T., Nguyen H.X., Dang P.H., Le T.M., Phan T.H.N., Tran A.H., Nguyen B.D., Ueda J., Awale S.
  Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity   
  Planta Med. 2014, 80, 193-200.
  
  
• Dibwe D. F., Awale S., Kadota S., Morita H., Tezuka Y. 
  Muchimangins G–J, Fully Substituted Xanthones with a Diphenylmethyl Substituent, from Securidaca longepedunculata. 
  J. Nat. Prod., 2014, 77, 1241−1244.
  

• Habibie, Yokoyama S., Abdelhamed S., Awale S., Sakurai H., Hayakawa Y., Saiki I. 
  Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. 
  Int. J. Oncol. 2014, 45, 895−901.

• Shakya B., Yadav P.N., Ueda J., Awale S.
  Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents
  Bioorg. Med. Chem. Lett.  2014, 24, 458-461.
  
• Dibwe D. F., Awale S., Kadota S., Morita H., Tezuka Y. 
  Two new diphenylmethyl-substituted xanthones from Securidaca longepedunculata. 
  Nat. Prod. Comm., 2014, 9, 655−657.
  
  

• Ueda J., Athikomkulchai S., Miyatake R., Saiki I., Esumi H., Awale S.
  (+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death  
  Drug Des. Dev. Ther. 2014, 8, 39-47. [Download article]
  
• Awale S., Kato M., Dibwe D.F., Li F., Miyoshi C., Esumi H., Kadota S., Tezuka Y.
  Antiausterity Activity of Arctigenin Enantiomers: Importance of (2R,3R)-Absolute Configuration
  Nat. Prod. Commun. 2014, 9, 79-82.
  
• Zhang H., Yamakawa Y., Matsuya Y., Toyooka N., Tohda C., Awale S., Li F., Kadota S, Tezuka Y.
  Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent.
  Bioorg. Med. Chem. Lett. 2014, 24, 604−608.
  
  

• Abdelhamed S., Yokoyama S., Refaat A., Ogura K., Yagita H., Awale S., Saiki I.
  Piperine Enhances the Efficacy of TRAIL-based Therapy for Triple-negative Breast Cancer Cells.
  Anticancer Res. 2014, 34, 1893−1899.
  
• Kato M., He Y., Dibwe D.F., Li F., Awale S., Kadota S., Tezuka Y.
  New Guaian-type Sesquiterpene from Wikstroemia indica
  Nat. Prod. Commun. 2014, 9, 1-2.

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• Dibwe D.F., Awale S., Kadota S., Morita H., Tezuka Y.
  Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata
  Bioorg. Med. Chem. 2013, 21, 7663-7668.

• Nguyen H.X., Nguyen M.T.T., Nguyen T.A., Nguyen N.Y.T., Phan D.A.T., Ho P.T., Phan T.H.N.,  Dang P.H., Nguyen N.T., Ueda J., Awale S.
  Cleistanthane Diterpenes from the Seed of Caesalpinia sappan and their antiausteriy activity against PANC-1 human pancreatic cancer cell line
  Fitoterapia, 2013, 91, 148-153.

• Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Maruyama T., Athikomkulchai S., Viriyaroj A., Awale S., Yagita H., Ruchirawat S., Svasti J., Saiki I.
  Chrysin decreases hypoxic survival and suppresses metastatic progression of mouse breast cancer cells
  Oncol Rep. 2013, 30, 2357-2364.

• Athikomkulchai S., Awale S.*, Ruangrungsi N., Ruchirawat S., Kadota S.
  Chemical Constituents of Thai propolis
  Fitoterapia, 2013, 88, 96-100.

• Lirdprapamongkol K., Sakurai H., Abdelhamed S., Yokoyama S., Athikomkulchai S., Viriyaroj A., Awale S., Ruchirawat S.,  Svasti J.,  Saiki I.
  Chrysin overcomos TRAIL resistance of cancer cells though Mcl-1 down-regulation by inhibiting STAT3 phoshorylation
  Int. J. Oncol., 2013, 43, 329-337.

• Abdelhamed S., Yokoyama S., Hafiyani L., Kalauni S.K., Hayakawa Y., Awale S., Saiki I.
  Identification of plant extracts sensitizing breast cancer cells to TRAIL
  Oncol Rep., 2013, 29, 1991-1998.

• Tezuka Y., Yamamoto K., Awale S., Feng L., Yomoda S., Kadota S.
  Anti-austeric activity of phenolic constituents of seeds of Arctium lappa
  Nat. Prod. Commun. 2013, 8, 463-466.

• Kudou N., Taniguchi A., Sugimoto K., Matsuya Y., Kawasaki M., Toyooka N., Miyoshi C., Awale S., Dibwe D.F., Esumi H., Kadota S., Tezuka Y.
  Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy
  Eur. J. Med. Chem. 2013, 60, 76-88.